WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=36; E=3.84; R=9.37; rawP=1.48e-24; adjP=2.15e-22
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000109332 NA UBE2D3 ubiquitin-conjugating enzyme E2D 3 7323 ENSG00000109332
2  ENSG00000157020 NA SEC13 SEC13 homolog (S. cerevisiae) 6396 ENSG00000157020
3  ENSG00000120694 NA HSPH1 heat shock 105kDa/110kDa protein 1 10808 ENSG00000120694
4  ENSG00000166598 NA HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 7184 ENSG00000166598
5  ENSG00000132432 NA SEC61G Sec61 gamma subunit 23480 ENSG00000132432
6  ENSG00000090520 NA DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 51726 ENSG00000090520
7  ENSG00000167004 NA PDIA3 protein disulfide isomerase family A, member 3 2923 ENSG00000167004
8  ENSG00000131871 NA VIMP VCP-interacting membrane protein 55829 ENSG00000131871
9  ENSG00000132002 NA DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3337 ENSG00000132002
10  ENSG00000180879 NA SSR4 signal sequence receptor, delta 6748 ENSG00000180879
11  ENSG00000112208 NA BAG2 BCL2-associated athanogene 2 9532 ENSG00000112208
12  ENSG00000155660 NA PDIA4 protein disulfide isomerase family A, member 4 9601 ENSG00000155660
13  ENSG00000179218 NA CALR calreticulin 811 ENSG00000179218
14  ENSG00000163902 NA RPN1 ribophorin I 6184 ENSG00000163902
15  ENSG00000185624 NA P4HB prolyl 4-hydroxylase, beta polypeptide 5034 ENSG00000185624
16  ENSG00000129562 NA DAD1 defender against cell death 1 1603 ENSG00000129562
17  ENSG00000118705 NA RPN2 ribophorin II 6185 ENSG00000118705
18  ENSG00000169223 NA LMAN2 lectin, mannose-binding 2 10960 ENSG00000169223
19  ENSG00000143870 NA PDIA6 protein disulfide isomerase family A, member 6 10130 ENSG00000143870
20  ENSG00000030110 NA BAK1 BCL2-antagonist/killer 1 578 ENSG00000030110
21  ENSG00000106803 NA SEC61B Sec61 beta subunit 10952 ENSG00000106803
22  ENSG00000128272 NA ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 468 ENSG00000128272
23  ENSG00000159461 NA AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 267 ENSG00000159461
24  ENSG00000197930 NA ERO1L ERO1-like (S. cerevisiae) 30001 ENSG00000197930
25  ENSG00000044574 NA HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 3309 ENSG00000044574
26  ENSG00000149428 NA HYOU1 hypoxia up-regulated 1 10525 ENSG00000149428
27  ENSG00000160087 NA UBE2J2 ubiquitin-conjugating enzyme E2, J2 118424 ENSG00000160087
28  ENSG00000086061 NA DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 3301 ENSG00000086061
29  ENSG00000058262 NA SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 29927 ENSG00000058262
30  ENSG00000072849 NA DERL2 derlin 2 51009 ENSG00000072849
31  ENSG00000134910 NA STT3A STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 3703 ENSG00000134910
32  ENSG00000136770 NA DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 64215 ENSG00000136770
33  ENSG00000100219 NA XBP1 X-box binding protein 1 7494 ENSG00000100219
34  ENSG00000131508 NA UBE2D2 ubiquitin-conjugating enzyme E2D 2 7322 ENSG00000131508
35  ENSG00000114850 NA SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 6747 ENSG00000114850
36  ENSG00000151092 NA NGLY1 N-glycanase 1 55768 ENSG00000151092


Database:KEGG pathway       Name:Ribosome biogenesis in eukaryotes       ID:03008
C=80; O=20; E=1.86; R=10.74; rawP=1.72e-15; adjP=1.25e-13
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152464 NA RPP38 ribonuclease P/MRP 38kDa subunit 10557 ENSG00000152464
2  ENSG00000163938 NA GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 26354 ENSG00000163938
3  ENSG00000165271 NA NOL6 nucleolar protein family 6 (RNA-associated) 65083 ENSG00000165271
4  ENSG00000107937 NA GTPBP4 GTP binding protein 4 23560 ENSG00000107937
5  ENSG00000241945 NA PWP2 PWP2 periodic tryptophan protein homolog (yeast) 5822 ENSG00000241945
6  ENSG00000105171 NA POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 10775 ENSG00000105171
7  ENSG00000134697 NA GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 29889 ENSG00000134697
8  ENSG00000130826 NA DKC1 dyskeratosis congenita 1, dyskerin 1736 ENSG00000130826
9  ENSG00000109534 NA GAR1 GAR1 ribonucleoprotein homolog (yeast) 54433 ENSG00000109534
10  ENSG00000055044 NA NOP58 NOP58 ribonucleoprotein homolog (yeast) 51602 ENSG00000055044
11  ENSG00000101361 NA NOP56 NOP56 ribonucleoprotein homolog (yeast) 10528 ENSG00000101361
12  ENSG00000104356 NA POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) 10940 ENSG00000104356
13  ENSG00000242372 NA EIF6 eukaryotic translation initiation factor 6 3692 ENSG00000242372
14  ENSG00000108651 NA UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 55813 ENSG00000108651
15  ENSG00000124383 NA MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 10199 ENSG00000124383
16  ENSG00000011260 NA UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 51096 ENSG00000011260
17  ENSG00000172336 NA POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 10248 ENSG00000172336
18  ENSG00000132341 NA RAN RAN, member RAS oncogene family 5901 ENSG00000132341
19  ENSG00000085231 NA TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 6880 ENSG00000085231
20  ENSG00000070770 NA CSNK2A2 casein kinase 2, alpha prime polypeptide 1459 ENSG00000070770


Database:KEGG pathway       Name:Shigellosis       ID:05131
C=61; O=14; E=1.42; R=9.86; rawP=1.02e-10; adjP=4.93e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000073009 NA IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 8517 ENSG00000073009
2  ENSG00000136950 NA ARPC5L actin related protein 2/3 complex, subunit 5-like 81873 ENSG00000136950
3  ENSG00000104312 NA RIPK2 receptor-interacting serine-threonine kinase 2 8767 ENSG00000104312
4  ENSG00000184009 NA ACTG1 actin, gamma 1 71 ENSG00000184009
5  ENSG00000150760 NA DOCK1 dedicator of cytokinesis 1 1793 ENSG00000150760
6  ENSG00000103653 NA CSK c-src tyrosine kinase 1445 ENSG00000103653
7  ENSG00000136238 NA RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 5879 ENSG00000136238
8  ENSG00000131508 NA UBE2D2 ubiquitin-conjugating enzyme E2D 2 7322 ENSG00000131508
9  ENSG00000161638 NA ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 3678 ENSG00000161638
10  ENSG00000075624 NA ACTB actin, beta 60 ENSG00000075624
11  ENSG00000241553 NA ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 10093 ENSG00000241553
12  ENSG00000104825 NA NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 4793 ENSG00000104825
13  ENSG00000116670 NA MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 10459 ENSG00000116670
14  ENSG00000111229 NA ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 10094 ENSG00000111229


Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=18; E=2.96; R=6.09; rawP=1.05e-09; adjP=3.81e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000168438 NA CDC40 cell division cycle 40 homolog (S. cerevisiae) 51362 ENSG00000168438
2  ENSG00000125870 NA SNRPB2 small nuclear ribonucleoprotein polypeptide B 6629 ENSG00000125870
3  ENSG00000125835 NA SNRPB small nuclear ribonucleoprotein polypeptides B and B1 6628 ENSG00000125835
4  ENSG00000162385 NA MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 4116 ENSG00000162385
5  ENSG00000092199 NA HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 3183 ENSG00000092199
6  ENSG00000183431 NA SF3A3 splicing factor 3a, subunit 3, 60kDa 10946 ENSG00000183431
7  ENSG00000141759 NA TXNL4A thioredoxin-like 4A 10907 ENSG00000141759
8  ENSG00000169564 NA PCBP1 poly(rC) binding protein 1 5093 ENSG00000169564
9  ENSG00000169976 NA SF3B5 splicing factor 3b, subunit 5, 10kDa 83443 ENSG00000169976
10  ENSG00000167088 NA SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 6632 ENSG00000167088
11  ENSG00000100410 NA PHF5A PHD finger protein 5A 84844 ENSG00000100410
12  ENSG00000141543 NA EIF4A3 eukaryotic translation initiation factor 4A3 9775 ENSG00000141543
13  ENSG00000164609 NA SLU7 SLU7 splicing factor homolog (S. cerevisiae) 10569 ENSG00000164609
14  ENSG00000116350 NA SRSF4 serine/arginine-rich splicing factor 4 6429 ENSG00000116350
15  ENSG00000114503 NA NCBP2 nuclear cap binding protein subunit 2, 20kDa 22916 ENSG00000114503
16  ENSG00000143977 NA SNRPG small nuclear ribonucleoprotein polypeptide G 6637 ENSG00000143977
17  ENSG00000119953 NA SMNDC1 survival motor neuron domain containing 1 10285 ENSG00000119953
18  ENSG00000198231 NA DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 11325 ENSG00000198231


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=18; E=3.52; R=5.12; rawP=1.72e-08; adjP=4.99e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000157020 NA SEC13 SEC13 homolog (S. cerevisiae) 6396 ENSG00000157020
2  ENSG00000072756 NA TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 51095 ENSG00000072756
3  ENSG00000131652 NA THOC6 THO complex 6 homolog (Drosophila) 79228 ENSG00000131652
4  ENSG00000152464 NA RPP38 ribonuclease P/MRP 38kDa subunit 10557 ENSG00000152464
5  ENSG00000104131 NA EIF3J eukaryotic translation initiation factor 3, subunit J 8669 ENSG00000104131
6  ENSG00000124571 NA XPO5 exportin 5 57510 ENSG00000124571
7  ENSG00000162385 NA MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 4116 ENSG00000162385
8  ENSG00000105171 NA POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 10775 ENSG00000105171
9  ENSG00000104356 NA POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) 10940 ENSG00000104356
10  ENSG00000125977 NA EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 8894 ENSG00000125977
11  ENSG00000108559 NA NUP88 nucleoporin 88kDa 4927 ENSG00000108559
12  ENSG00000084623 NA EIF3I eukaryotic translation initiation factor 3, subunit I 8668 ENSG00000084623
13  ENSG00000141543 NA EIF4A3 eukaryotic translation initiation factor 4A3 9775 ENSG00000141543
14  ENSG00000172336 NA POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 10248 ENSG00000172336
15  ENSG00000152147 NA GEMIN6 gem (nuclear organelle) associated protein 6 79833 ENSG00000152147
16  ENSG00000114503 NA NCBP2 nuclear cap binding protein subunit 2, 20kDa 22916 ENSG00000114503
17  ENSG00000132341 NA RAN RAN, member RAS oncogene family 5901 ENSG00000132341
18  ENSG00000151247 NA EIF4E eukaryotic translation initiation factor 4E 1977 ENSG00000151247


Database:KEGG pathway       Name:Protein export       ID:03060
C=23; O=8; E=0.54; R=14.94; rawP=3.02e-08; adjP=7.30e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144867 NA SRPRB signal recognition particle receptor, B subunit 58477 ENSG00000144867
2  ENSG00000106803 NA SEC61B Sec61 beta subunit 10952 ENSG00000106803
3  ENSG00000182934 NA SRPR signal recognition particle receptor (docking protein) 6734 ENSG00000182934
4  ENSG00000058262 NA SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 29927 ENSG00000058262
5  ENSG00000132432 NA SEC61G Sec61 gamma subunit 23480 ENSG00000132432
6  ENSG00000044574 NA HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 3309 ENSG00000044574
7  ENSG00000118363 NA SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 9789 ENSG00000118363
8  ENSG00000129128 NA SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 60559 ENSG00000129128


Database:KEGG pathway       Name:Lysosome       ID:04142
C=121; O=15; E=2.82; R=5.33; rawP=1.57e-07; adjP=3.25e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117410 NA ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 533 ENSG00000117410
2  ENSG00000135535 NA CD164 CD164 molecule, sialomucin 8763 ENSG00000135535
3  ENSG00000135404 NA CD63 CD63 molecule 967 ENSG00000135404
4  ENSG00000174080 NA CTSF cathepsin F 8722 ENSG00000174080
5  ENSG00000109323 NA MANBA mannosidase, beta A, lysosomal 4126 ENSG00000109323
6  ENSG00000141012 NA GALNS galactosamine (N-acetyl)-6-sulfate sulfatase 2588 ENSG00000141012
7  ENSG00000070718 NA AP3M2 adaptor-related protein complex 3, mu 2 subunit 10947 ENSG00000070718
8  ENSG00000125447 NA GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 23163 ENSG00000125447
9  ENSG00000119655 NA NPC2 Niemann-Pick disease, type C2 10577 ENSG00000119655
10  ENSG00000100280 NA AP1B1 adaptor-related protein complex 1, beta 1 subunit 162 ENSG00000100280
11  ENSG00000177879 NA AP3S1 adaptor-related protein complex 3, sigma 1 subunit 1176 ENSG00000177879
12  ENSG00000102805 NA CLN5 ceroid-lipofuscinosis, neuronal 5 1203 ENSG00000102805
13  ENSG00000159720 NA ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 9114 ENSG00000159720
14  ENSG00000038002 NA AGA aspartylglucosaminidase 175 ENSG00000038002
15  ENSG00000204386 NA NEU1 sialidase 1 (lysosomal sialidase) 4758 ENSG00000204386


Database:KEGG pathway       Name:N-Glycan biosynthesis       ID:00510
C=49; O=9; E=1.14; R=7.89; rawP=1.73e-06; adjP=3.14e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000214160 NA ALG3 asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae) 10195 ENSG00000214160
2  ENSG00000086848 NA ALG9 asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae) 79796 ENSG00000086848
3  ENSG00000136908 NA DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 8818 ENSG00000136908
4  ENSG00000163902 NA RPN1 ribophorin I 6184 ENSG00000163902
5  ENSG00000134910 NA STT3A STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 3703 ENSG00000134910
6  ENSG00000129562 NA DAD1 defender against cell death 1 1603 ENSG00000129562
7  ENSG00000159063 NA ALG8 asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) 79053 ENSG00000159063
8  ENSG00000172269 NA DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 1798 ENSG00000172269
9  ENSG00000118705 NA RPN2 ribophorin II 6185 ENSG00000118705


Database:KEGG pathway       Name:Vibrio cholerae infection       ID:05110
C=54; O=9; E=1.26; R=7.16; rawP=4.03e-06; adjP=6.49e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117410 NA ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 533 ENSG00000117410
2  ENSG00000106803 NA SEC61B Sec61 beta subunit 10952 ENSG00000106803
3  ENSG00000058262 NA SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 29927 ENSG00000058262
4  ENSG00000184009 NA ACTG1 actin, gamma 1 71 ENSG00000184009
5  ENSG00000132432 NA SEC61G Sec61 gamma subunit 23480 ENSG00000132432
6  ENSG00000197930 NA ERO1L ERO1-like (S. cerevisiae) 30001 ENSG00000197930
7  ENSG00000075624 NA ACTB actin, beta 60 ENSG00000075624
8  ENSG00000159720 NA ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 9114 ENSG00000159720
9  ENSG00000155660 NA PDIA4 protein disulfide isomerase family A, member 4 9601 ENSG00000155660


Database:KEGG pathway       Name:Bacterial invasion of epithelial cells       ID:05100
C=70; O=10; E=1.63; R=6.14; rawP=5.01e-06; adjP=7.26e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136950 NA ARPC5L actin related protein 2/3 complex, subunit 5-like 81873 ENSG00000136950
2  ENSG00000184009 NA ACTG1 actin, gamma 1 71 ENSG00000184009
3  ENSG00000150760 NA DOCK1 dedicator of cytokinesis 1 1793 ENSG00000150760
4  ENSG00000145675 NA PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5295 ENSG00000145675
5  ENSG00000136238 NA RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 5879 ENSG00000136238
6  ENSG00000161638 NA ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 3678 ENSG00000161638
7  ENSG00000075624 NA ACTB actin, beta 60 ENSG00000075624
8  ENSG00000241553 NA ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 10093 ENSG00000241553
9  ENSG00000116670 NA MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 10459 ENSG00000116670
10  ENSG00000111229 NA ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 10094 ENSG00000111229




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).